Trials / Completed
CompletedNCT02434627
Sodium Nitrate for Muscular Dystrophy
- Status
- Completed
- Phase
- Phase 1
- Study type
- Interventional
- Enrollment
- 5 (actual)
- Sponsor
- Cedars-Sinai Medical Center · Academic / Other
- Sex
- Male
- Age
- 15 Years – 45 Years
- Healthy volunteers
- Not accepted
Summary
The investigators' previous work in males with Becker Muscular Dystrophy shows that functional sympatholysis is restored by acute inorganic nitrate supplementation. This was translated from work using the mdx mouse model of dystrophinopathy. Recent work has shown that there is a frank improvement in grip strength when mdx mice are treated with an inorganic Nitric Oxide (NO) donor. The purpose of this study is to determine if chronic treatment with an inorganic NO donor can benefit patients with muscular dystrophy beyond blood flow regulation.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Sodium Nitrate | Patients will be given sodium nitrate daily in the form of beetroot juice. |
Timeline
- Start date
- 2015-06-01
- Primary completion
- 2018-04-01
- Completion
- 2018-04-01
- First posted
- 2015-05-05
- Last updated
- 2020-01-13
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT02434627. Inclusion in this directory is not an endorsement.