NCT02429817

Tomographic Comparison of Aerosol Lung Distribution With Two Nebulizers Through a High Flow Nasal Cannula

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 6 (actual)
• Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Academic / Other
• Sex: Male
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Vibrating-mesh nebulizers ensure currently the best deposition output and are recommended in routine use in intensive care unit. However, jet nebulizers remain the most frequently used nebulizers. On a bench study, aerosol delivery through a high flow nasal cannula (HFNC) was increased using a vibrating-mesh nebulizer as compared to a jet nebulizer. Lung distribution of nebulized particles delivered through a HFNC has never been investigated in vivo. The aim of this study was to compare aerosol lung distribution with both nebulizers through a HFNC by SPECT-CT.

Conditions

• Healthy

Interventions

Type	Name	Description
DRUG	Technetium-99m - Diethylenetriaminepentaacetic acid	99mTc-DTPA solution placed on the nebulizer reservoir
DEVICE	Aeroneb Solo
DEVICE	Jet Nebulizer
OTHER	Single photon emission computed tomography	Imaging technique to investigate lung aerosol distribution
OTHER	Spirometry	FEV1, FVC assessment

Timeline

• Start date: 2015-04-01
• Primary completion: 2016-12-01
• Completion: 2016-12-01
• First posted: 2015-04-29
• Last updated: 2016-12-05

Locations

1 site across 1 country: Belgium