Trials / Completed
CompletedNCT02425774
Anti-inflammatory Effect of Pre-operative Stimulation of the Cholinergic Anti-Inflammatory Pathway
Anti-inflammatory Effect of Pre-operative Stimulation of the Cholinergic Anti-Inflammatory Pathway: A Potential New Therapeutical Intervention for Postoperative Ileus
- Status
- Completed
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 31 (actual)
- Sponsor
- KU Leuven · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Hypothesis: Prucalopride can mimic electrical stimulation of the abdominal vagus nerve and has an anti-inflammatory effect. Aims: In the present pilot study, the investigators want to evaluate the anti-inflammatory effect of prucalopride. The following aims are formulated: 1. to show that prucalopride has a similar inflammatory effect as abdominal vagus nerve stimulation (VNS) 2. to evaluate whether prucalopride leads to accelerated post-operative recovery
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Vagus stimulation | |
| PROCEDURE | Sham stimulation | |
| DRUG | Prucalopride | |
| DRUG | Placebo |
Timeline
- Start date
- 2014-07-01
- Primary completion
- 2016-02-27
- Completion
- 2016-02-27
- First posted
- 2015-04-24
- Last updated
- 2026-03-20
Locations
1 site across 1 country: Belgium
Source: ClinicalTrials.gov record NCT02425774. Inclusion in this directory is not an endorsement.