NCT02422732

Functional Imaging and Reading Deficit in Children With NF1

Functional Magnetic Resonance Imaging and Reading Deficit in Children With NF1 Children

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 25 (actual)
• Sponsor: University Hospital, Toulouse · Academic / Other
• Sex: All
• Age: 8 Years – 12 Years
• Healthy volunteers: Not accepted

Summary

A monocenter pilot study on the acceptability and feasibility of a functional MRI protocol in children with NF1 with or without reading disabilities.

Detailed description

The principal aim of the study is to highlight the activation of brain area involved phonological and visuo-spatial processing in children with NF1 with or without reading disabilities.

Conditions

• Neurofibromatosis Type 1

Interventions

Type	Name	Description
OTHER	Neuropsychological assessments	IQ (WISC-IV) Reading tests (reading accuracy, reading speed, reading comprehension and strategy): Alouette, Lobrot, Odedys tests. Visuo-spatial skill (JLO, Thurston, CORSI tests) Attention (CPT 2, CBCL) Receptive oral language (EVIP)
RADIATION	morphological and functional MRI (fMRI)	The fMRI will consider on the acquisition of a 3D anatomical sequence in T1 high resolution in axial slices of 1mm with an acquisition time of 10 min and a T2 sequence and a "Flair" to allow UBO location.
GENETIC	genetic analysis	Blood collection in 3 tubes (2 PAXgen® and 1 EDTA) and analysis to study the NF1 gene deletion.

Timeline

• Start date: 2009-03-01
• Primary completion: 2015-04-01
• Completion: 2015-04-01
• First posted: 2015-04-21
• Last updated: 2015-08-19

Locations

1 site across 1 country: France