NCT02421627

Moxibustion for Diarrhea-predominant Irritable Bowel Syndrome

Study on the Mechanism of Moxibustion Effect on Treating Diarrhea-predominant Irritable Bowel Syndrome

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 104 (actual)
• Sponsor: Shanghai Institute of Acupuncture, Moxibustion and Meridian · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

To observe the safety and efficacy of moxibustion on diarrhea-predominant irritable bowel syndrome and evaluation by Magnetic Resonance Imaging (MRI), Event related potential (ERP).

Detailed description

1. A randomized controlled trial 2. Moxibustion treatment, sham control 3. To observe the safety and efficacy of moxibustion treatment versus placebo control 4. Evaluation by intestinal microbial structural and diversity changes using 16S rDNA sequencing 5. Evaluation by structural MRI and resting state-functional MRI 6. Evaluation by ERP

Conditions

• Irritable Bowel Syndrome

Interventions

Type	Name	Description
DEVICE	moxibustion	Acupoints: Tianshu (ST25，bilateral), Zusanli (ST36，bilateral). using mild-warm moxibustion，the surface temperature of acupoints were maintained at 43 ℃ ± 1 ℃, 30min for each acupoint, once every other day, three times a week, a total of six weeks treatment. After the treatment, subjects were followed up at weeks 12, 18 and 24.
DEVICE	Sham moxibustion	Acupoints: Tianshu (ST25，bilateral), Zusanli (ST36，bilateral); using sham mild-warm moxibustion，the surface temperature of acupoints were maintained at 37 ℃ ± 1 ℃, 30min for each acupoint, once every other day, three times a week, a total of six weeks treatment. After the treatment, subjects were followed up at weeks 12, 18 and 24.

Timeline

• Start date: 2015-04-01
• Primary completion: 2018-12-31
• Completion: 2018-12-31
• First posted: 2015-04-20
• Last updated: 2020-02-10

Locations

3 sites across 1 country: China