NCT02418234

T790M Mutation on ctDNA in Patients With NSCLC After EGFR-TKI Failure

Frequency and Abundance of T790M Mutation on Circulating Tumor DNA in Patients With Non-small Cell Lung Cancer After Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors Treatment Failure: a Perspective Observational Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 314 (actual)
• Sponsor: First People's Hospital of Hangzhou · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to compare the frequency and abundance of T790M mutation among the different Clinical modes of EGFR-TKI failure.

Detailed description

An observational, non-interventional, multi-central study of comparison of the frequency and abundance of T790M mutation using both amplification refractory mutation system (ARMS) and digital droplet PCR (ddPCR) methods among the different Clinical modes of non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) failure

Conditions

• Non-small Cell Lung Cancer Stage III
• Non-Small-Cell Lung Cancer Metastatic

Interventions

Type	Name	Description
OTHER	mutation detection
OTHER	ARMS and ddPCR
GENETIC	ctDNA analysis

Timeline

• Start date: 2015-03-01
• Primary completion: 2016-04-01
• Completion: 2017-11-01
• First posted: 2015-04-16
• Last updated: 2018-03-12
• Results posted: 2016-08-08

Locations

1 site across 1 country: China