NCT02416609

Low-dose Radiotherapy Plus Chemotherapy With Gem-based Doublets and Stereotactic Radiotherapy for Advanced Pancreatic Cancer

Low-dose Radiotherapy as a Chemo-potentiator of a Induction Chemotherapy Regimen With Gem-based Doublets and Stereotactic Body Radiotherapy for Locally Advanced Pancreatic Cancer

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 44 (estimated)
• Sponsor: Azienda Ospedaliero-Universitaria di Modena · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Aim of this study is to evaluate if low-dose radiotherapy (LDR) can intensify local effect of a chemotherapy regimen with Gem-based doublets administered sequentially with stereotactic body radiotherapy (SBRT) and to assess the safety and efficacy of this combined treatment on patients affected by locally advanced pancreatic adenocarcinoma (LAPC).

Conditions

• Pancreatic Cancer

Interventions

Type	Name	Description
RADIATION	LDR	LDR will be delivered during each cycle of Gem-based doublets
DRUG	Gem-based doublets	4 cycles of Gem-based doublets
RADIATION	SBRT	SBRT will be administered after the fourth Gem-based doblet cycle, if no progression; three fractions will be administered

Timeline

• Start date: 2014-01-01
• Primary completion: 2023-11-01
• Completion: 2024-11-01
• First posted: 2015-04-15
• Last updated: 2022-12-12

Locations

1 site across 1 country: Italy