NCT02412189

Pressure-dependent Changes in Hematocrit and Plasma Volume During Anesthesia

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (estimated)
• Sponsor: Sahlgrenska University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The arterial blood pressure affects the ratio between filtration and reabsorption of fluids in the circulating blood volume and thereby the hematocrit. During induction of anesthesia blood pressure, hemoglobin level and hematocrit decreases. The aim of the study is to evaluate weather a maintained blood pressure with norepinephrine during anesthesia induction reduces the decrease in hematocrit.

Detailed description

24 patients scheduled for coronary artery bypass surgery will be included and randomized to receive either norepinephrine in the dose needed to maintain pre-anesthesia blood pressure or to a control group and receive norepinephrine only if mean arterial pressure decreases below 60 mmHg. Arterial blood gas will be analysed every ten minutes. Equal anesthesia in both groups will be monitored. No fluids will be infused. Noninvasive continuous hemoglobin measurement (SpHb) will be measured.

Conditions

• Blood Pressure
• Hematocrit Change
• Anesthesia

Interventions

Type	Name	Description
PROCEDURE	Maintained blood pressure	Norepinephrine therapy to maintain preanesthesia blood pressure
DRUG	Norepinephrine	Norepinephrine therapy to maintain preanesthesia blood pressure

Timeline

• Start date: 2014-02-01
• Primary completion: 2015-04-01
• Completion: 2015-05-01
• First posted: 2015-04-09
• Last updated: 2015-04-09

Locations

1 site across 1 country: Sweden