NCT02412150

Effect of Dexmedetomidine After Thyroidectomy

Effect of Dexmedetomidine Infusion for Postoperative Outcome and Smooth Emergence After Thyroidectomy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 139 (actual)
• Sponsor: Chosun University Hospital · Academic / Other
• Sex: Female
• Age: 20 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The purpose of the present study was to compare the effect of dexmedetomidine which is administered during emergence in adult patients undergoing elective thyroidectomy on smooth emergence form general anesthesia (reducing agitation or coughing, signs of hypertension or tachycardia, or etc.) and postoperative outcome (postoperative bleeding and hospital staying).

Detailed description

Smooth emergence from general anaesthesia after surgery is important to prevent potentially dangerous effects such as hypertension, tachycardia, myocardial ischaemia, arrhythmias and increased intracranial and intra-abdominal pressure. After thyroidectomy, activities during emergence such as agitation or coughing, signs of hypertension or tachycardia, or etc. may lead to postoperative bleeding, resulting in acute airway obstruction or reoperation. The purpose of the present study was to compare the effect of dexmedetomidine which is administered during emergence in adult patients undergoing elective thyroidectomy on smooth emergence form general anesthesia and postoperative outcome.

Conditions

• Thyroid Tumor

Interventions

Type	Name	Description
DRUG	Desflurane	Anesthesia is maintained with desflurane
DRUG	Remifentanil	Remifentanil is infused for the maintenance of anesthesia during surgery and discontinued 15 min before end of surgery
PROCEDURE	Thyroidectomy	The aim of this study is evaluation of effect of dexmedetomidine on emergence response and postoperative outcome after thyroidectomy
OTHER	Vital signs	Systolic blood pressure, diastolic blood pressure, mean arterial pressure, and heart rate are measured before infusion of testing drugs, after infusion of them (5 min, 10 min, and 15 min), during extubation (0 min and 5 min after extubation), and at recovery room. And the complications such as hypotension, hypertension, bradycardia, tachycardia, and desaturation after infusion of testing drugs are observed.
BEHAVIORAL	Cough reflex	During recovery from anesthesia at operation room, cough reflex is measured and rated. \[Grade 0, no cough; Grade 1, single cough with mild severity; Grade 2, cough persistence less than 5 s with moderate severity; Grade 3, severe, persistent cough for more than 5 s (bucking)\]
BEHAVIORAL	Ramsay Sedation Scale	When the patient has fully awaken and transferred to the recovery room, Ramsay Sedation Scale is measured. 1. Awake Patient anxious and agitated or restless or both! 2. Patient cooperative, oriented and tranquil! 3. Patient responds to commands only! 4. Asleep A brisk response to a light glabellar tap or loud auditory stimulus! 5. A sluggish response to a light glabellar tap or loud auditory stimulus! 6. No response to a light glabellar tap or loud auditory stimulus
OTHER	Extubation time and Recovery time	The time from discontinuing anesthetic gas to endotracheal extubation is measured. And the time from the discontinuing of anesthetic gas to transferring to the recovery room is also measured.
BEHAVIORAL	Visual analogue scale	The severity of pain after surgery is measured by VAS (at recovery room, POD 1, POD 2, and POD 3)
OTHER	Postoperative bleeding	The amount of postoperative bleeding which is collected in the barovac is measured.
OTHER	Postoperative complications	Postoperative complications after thyroidectomy such as hoarseness and hematoma, and reoperation due to such complication is observed.
OTHER	Time to remove drainage and duration of hospital staying	The time from the end of surgery to remove drainage is measured. And the duration of hospital staying is measured.
DRUG	Dexmedetomidine	Dexmedetomidine has started infusion for 15 min (rate of 0.6 ug/kg/hr) before end of surgery as experimental intervention
DRUG	Normal saline	Normal saline has started infusion for 15 min (as same rate of dexmedetomidine) before end of surgery as control intervention

Timeline

• Start date: 2014-04-01
• Primary completion: 2020-11-21
• Completion: 2020-11-25
• First posted: 2015-04-09
• Last updated: 2020-11-27

Locations

1 site across 1 country: South Korea