NCT02411682

Breakfast on Postprandial Hyperglycemia

Effect of Breakfast on Overall Postprandial Hyperglycemia in T2D

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 28 (estimated)
• Sponsor: Hospital de Clinicas Caracas · Academic / Other
• Sex: All
• Age: 30 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Reduction of postprandial hyperglycemia (PPHG) is a major target in the treatment of type 2 diabetes (T2D). Skipping breakfast has been consistently associated with higher HbA1c and overall PPHG in subjects with type 2 diabetes (T2D). Our aim was to explore the effect of skipping vs eating breakfast on PPHG after subsequent isocaloric (700kcal) lunch and dinner

Detailed description

In type 2 diabetic individuals the omission of breakfast is associated with significant increase in HbA1C and all-day postprandial hyperglycemia even without overeating in the evening. In contrast, high-energy breakfast and low-energy dinner result in a significant reduction of all-day postprandial glycaemia Similarly, 3 months of high-energy breakfast led to a 5% reduction in HbA1C levels in type 2 diabetes participants Despite the growing evidence showing the beneficial effects of breakfast consumption on overall postprandial hyperglycemia and HbA1C levels, very little is known regarding the relationship between breakfast skipping and all-day glycemic excursions in type 2 diabetes patients. Therefore, to test whether breakfast skipping influences metabolic responses to the following meals in type 2 diabetes patients during the same day, we explored the postprandial glycemic response to identical lunch and dinner meal tests with or without breakfast.

Conditions

• Type 2 Diabetes

Interventions

Type	Name	Description
OTHER	Breakfast eating (YesB)	On YesB day the patients will eat Breakfast at 8:00, Lunch at 13:30 and Dinner at 19:00
OTHER	Breakfast skipping (NoB)	On NoB day the patients will fast until lunch, then will eat Lunch at 13:30 and Dinner at 19:00

Timeline

• Start date: 2014-05-01
• Primary completion: 2014-07-01
• Completion: 2015-04-01
• First posted: 2015-04-08
• Last updated: 2015-04-08