NCT02410096

Bronchial Inflammation and Hyperresponsiveness After Oil Supplementation

Examination of Bronchial Inflammation and Hyperresponsiveness After Oil Supplementation With Middle-chain and Polyunsaturated Fatty Acids in an Exercise-induced Asthma Provocation Model

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 73 (actual)
• Sponsor: Johann Wolfgang Goethe University Hospital · Academic / Other
• Sex: All
• Age: 12 Years – 44 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to investigate the bronchial inflammation and hyperresponsiveness after oil supplementation. Before and after oil supplementation the investigators measure decrease in lung function after exercise-challenge in a cold chamber and increase of inflammatory markers in the blood.

Detailed description

Subjects suffering form exercise-induced bronchoconstriction (EIB) usually have a normal lung function testing at rest and show a decrease in lung function when they do sports or an exercise-challenge. In a previous study the investigators could show, that the combination of exercise test and inhalation of cold air ist more sensitive and specific than exercise-challenge in ambient temperature. It is known that omega - 3 -fatty acids could reduce the production of inflammatory mediators. In this study the investigators will investigate the protective effect of oil supplementation with middle-chain and polyunsaturated fatty acids in an exercise-induced asthma provocation model. Therefore the investigators will measure the decrease in lung function and a increase of inflammatory markers in the blood before and after oil supplementation. Before and after the exercise-challenge the investigators will measure spirometry and body plethysmography. The investigators want to examine if the body plethysmography is more sensitive in the measurement of exercise induced bronchoconstriction than spirometry. The investigators hypothesize that the oil supplementation can reduce bronchial inflammation and hyperresponsiveness.

Conditions

• Exercise-induced Asthma

Interventions

Type	Name	Description
OTHER	Exercise challenge in a cold chamber	Exercise challenge is defined as running on a treadmill for 6-8 minutes on submaximal work load in a cold chamber.
OTHER	Methacholine challenge	Nebulized metacholine administered at following doses: 0,01mg, 0,1mg, 0,4mg, 0,8mg und 1,6mg
DIETARY_SUPPLEMENT	Oil supplementation verum	Patients and subjects will take double blind an oil supplementation with middle-chain and polyunsaturated fatty acids for four weeks
DIETARY_SUPPLEMENT	Oil supplementation placebo	Patients and subjects will take double blind sunflower oil for four weeks

Timeline

• Start date: 2015-04-01
• Primary completion: 2016-02-01
• Completion: 2016-07-01
• First posted: 2015-04-07
• Last updated: 2016-09-05

Locations

1 site across 1 country: Germany