NCT02409927

Effect of MCT Emulsification on Ketogenesis in Human Adults

Effect of Medium-chain Triglycerides Emulsification on Ketogenesis and Adverse Effects in Human Adults

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Université de Sherbrooke · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Lower brain glucose uptake is present before the onset of cognitive deterioration and may increase the risk of cognitive decline in Alzheimer's disease. Ketones are the brain's main alternative energy substrates. Medium-chain triglycerides (MCT) are rapidly beta-oxidized and are ketogenic. Large doses of MCT oil are linked to gastro-intestinal side effects due to incomplete absorption so the investigators examined whether homogenisation into a skim milk matrix (MCT-H) would both improve ketogenesis and reduce side-effects compared to MCT taken without homogenisation into a matrix (bulk MCT \[MCT-B\]). Hypotheses: (i) MCT-H will be better absorbed compared to MCT-B, so MCT-H will result in higher ketonemia and lower side effects in healthy adults. (ii) The effects of MCT-B and MCT-H on ketogenesis will be dose-dependent.

Conditions

• Healthy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	MCT oil 10g	10 g of pure MCT oil mixed with skim milk in a standardized breakfast
DIETARY_SUPPLEMENT	MCT homogenate 10g	10g provided by 10% MCT homogenate mixed with skim milk in a standardized breakfast
DIETARY_SUPPLEMENT	Control	vehicule (skim milk) with a standardized breakfast
DIETARY_SUPPLEMENT	MCT oil 20g	20g of pure MCT oil mixed with skim milk in a standardized breakfast
DIETARY_SUPPLEMENT	MCT homogenate 20g	20g provided by 10% MCT homogenate mixed with skim milk in a standardized breakfast
DIETARY_SUPPLEMENT	MCT oil 30g	30g of 100% pure MCT oil mixed with skim milk in a standardized breakfast
DIETARY_SUPPLEMENT	MCT homogenate 30g	30g provided by 10% MCT homogenate mixed with skim milk in a standardized breakfast

Timeline

• Start date: 2013-07-01
• Primary completion: 2014-09-01
• Completion: 2014-09-01
• First posted: 2015-04-07
• Last updated: 2019-02-11
• Results posted: 2018-12-17