Trials / Completed
CompletedNCT02409784
PET Study of Cerebral Metabolism of 11C-acetoacetate and 18F-FDG in Patients Under Moderate Ketosis
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 10 (actual)
- Sponsor
- Université de Sherbrooke · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
Regional brain glucose hypometabolism occurs during aging and may contribute to the onset of aging-related cognitive impairment in humans. Ketones are the main alternative energy substrate to glucose for the brain. Several studies show that brain ketone uptake and metabolism are unaltered in cognitively-normal older persons and in Alzheimer's disease (AD). Nutritional ketosis is reported to have a positive impact on cognitive performances in mild cognitive impairment and AD. Nevertheless, changes in regional brain glucose and ketone uptake in adults are poorly understood during diet-induced experimental ketosis. The investigators hypothesis was that during diet-induced ketosis, brain ketone uptake would be directly correlated with the elevation of blood ketone levels and inversely correlated to brain glucose uptake.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIETARY_SUPPLEMENT | Pre-KD | Before starting 4 days of 4:1 (lipids:protein/carbohydrates) ketogenic diet |
| DIETARY_SUPPLEMENT | Post-KD | After 4 days of 4:1 (lipids:protein/carbohydrates) ketogenic diet |
Timeline
- Start date
- 2014-03-01
- Primary completion
- 2015-01-01
- Completion
- 2015-01-01
- First posted
- 2015-04-07
- Last updated
- 2019-02-15
- Results posted
- 2018-04-06
Source: ClinicalTrials.gov record NCT02409784. Inclusion in this directory is not an endorsement.