NCT02405195

Renal Perfusion, Filtration and Oxygenation During Cardiopulmonary Bypass (CPB)

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 28 (actual)
• Sponsor: Sahlgrenska University Hospital · Academic / Other
• Sex: All
• Age: 19 Years
• Healthy volunteers: Not accepted

Summary

Acute kidney injury is a common complication after cardiac surgery with cardiopulmonary bypass (CPB). This study aims to investigate the effects of CPB on renal perfusion, filtration and oxygenation.

Detailed description

After approval of the regional ethics committee, patients (n=16) undergoing combined cardiac surgery procedures during normothermic CPB will be included after informed consent. Systemic and renal variables will be measured by pulmonary artery and renal vein catheters. Glomerular filtration rate (GFR) will be measured by renal extraction of 51Cr-EDTA and renal blood flow (RBF) by the infusion clearance technique for para-aminohippuric acid (PAH) corrected for by renal extraction of PAH. Repeated measures ANOVA followed by Fisher's PLSD post-hoc test were used for statistical analyses

Conditions

• Complication of Extracorporeal Circulation
• Renal Impairment

Interventions

Type	Name	Description
PROCEDURE	cardiopulmonary bypass	During cardiac surgery, the subjects are routinely undergoing cardiopulmonary bypass

Timeline

• Start date: 2011-10-01
• Primary completion: 2015-12-01
• Completion: 2016-01-01
• First posted: 2015-04-01
• Last updated: 2019-05-07
• Results posted: 2019-05-07

Locations

1 site across 1 country: Sweden