NCT02404792

Exercise for Healthy Aging: The Impact of HIV and Aging on Physical Function and the Somatopause

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 69 (actual)
• Sponsor: University of Colorado, Denver · Academic / Other
• Sex: All
• Age: 50 Years – 75 Years
• Healthy volunteers: Accepted

Summary

The primary objective of this proposal is to compare a moderate or high intensity exercise intervention to improve physical function in persons aging with Human Immunodeficiency Virus (HIV).

Detailed description

The primary objective of this proposal is to compare a moderate or high intensity exercise intervention to improve physical function in persons aging with HIV. Both HIV-infected and HIV-uninfected older adults will be assigned to a moderate intensity cardiovascular and resistance training intervention for 12 weeks, and then randomized to either continue moderate intensity exercise, or increase to high intensity exercise for an additional 12 weeks. The primary outcome is the impact of exercise on physical function, as measured by the overall score of a modified Short Physical Performance Battery (mSPPB) and the chair rise time from the mSPPB. The secondary outcomes include changes in insulin-like growth factor-1 (systemic and local) and inflammation (interleukin-6 (IL-6), soluble tumor necrosis factor receptors 1 and 2 (sTNFR-1 and sTNFR-2)).

Conditions

• HIV
• Inflammation
• Obesity
• Aging, Biological

Interventions

Type	Name	Description
OTHER	High-intensity cardiovascular and resistance exercise
OTHER	Moderate-intensity cardiovascular and resistance exercise

Timeline

• Start date: 2015-04-01
• Primary completion: 2017-10-02
• Completion: 2018-03-01
• First posted: 2015-04-01
• Last updated: 2019-01-16
• Results posted: 2019-01-16

Locations

1 site across 1 country: United States