NCT02402244

Project: Every Child for Younger Patients With Cancer

The Project: EveryChild Protocol: A Registry, Eligibility Screening, Biology and Outcome Study

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 75,000 (estimated)
• Sponsor: Children's Oncology Group · Network
• Sex: All
• Age: 25 Years
• Healthy volunteers: Not accepted

Summary

This study gathers health information for the Project: Every Child for younger patients with cancer. Gathering health information over time from younger patients with cancer may help doctors find better methods of treatment and on-going care.

Detailed description

PRIMARY OBJECTIVES: I. To maintain a Childhood Cancer Registry for infants, children, adolescents, and young adults with cancer. II. To utilize clinical and biological data to help determine eligibility or stratification, based on childhood cancer disease classification schemas, for potential enrollment of research subjects onto Children's Oncology Group (COG) therapeutic clinical trials. III. To develop a well annotated childhood cancer biorepository for current and future research through the collection of biospecimens (at diagnosis, time of progression, time of recurrence and/or post-mortem), including tumor, host and when feasible parental germline deoxyribonucleic acid (DNA); and key clinical data, including presentation, diagnostic, staging, summary treatment, and outcome information, from every child diagnosed with cancer at COG institutions. IV. To allow permission to be contacted in the future to consider participating in non-therapeutic and prevention research studies involving the patient or their parents (if applicable). V. For patients enrolled through adult cooperative groups, to develop a well annotated adolescent and young adult (AYA) cancer biorepository and to screen for eligibility for current and future research through the collection of biospecimens (at diagnosis, time of progression and time of recurrence), including tumor and host DNA; and key clinical data, including presentation, diagnostic, staging, and summary treatment information. OUTLINE: This is an observational study. Patients are assigned to 1 of 2 protocols. PROJECT: EVERY CHILD PROTOCOL: Patients undergo medical data review to create a Childhood Cancer Registry. Patients also undergo collection of biospecimen samples (e.g., tissue, blood, bone marrow, plasma, serum, buccal swab, saliva, cerebrospinal fluid, or urine). PROJECT AYA PROTOCOL: Patients undergo collection of biospecimen samples (e.g., tissue, blood, bone marrow, plasma, serum, buccal swab, saliva, cerebrospinal fluid, or urine).

Conditions

• Adrenal Gland Pheochromocytoma
• Carcinoma In Situ
• Central Nervous System Neoplasm
• Childhood Immature Teratoma
• Childhood Kidney Neoplasm
• Childhood Langerhans Cell Histiocytosis
• Childhood Mature Teratoma
• Congenital Mesoblastic Nephroma
• Desmoid Fibromatosis
• Ganglioneuroma
• Lymphoproliferative Disorder
• Malignant Neoplasm
• Malignant Solid Neoplasm
• Melanocytic Neoplasm
• Myeloproliferative Neoplasm
• Neoplasm of Uncertain Malignant Potential
• Neuroendocrine Neoplasm
• Stromal Neoplasm

Interventions

Type	Name	Description
OTHER	Cytology Specimen Collection Procedure	Undergo cytology specimen collection
OTHER	Medical Chart Review	Undergo medical data review

Timeline

• Start date: 2015-11-03
• Primary completion: 2030-12-31
• Completion: 2030-12-31
• First posted: 2015-03-30
• Last updated: 2026-02-27

Locations

278 sites across 6 countries: United States, Australia, Canada, New Zealand, Puerto Rico, Saudi Arabia