NCT02399306

Chemoradiotherapy With or Without Enteral Nutrition for Locally Advanced Thoracic Esophageal Carcinoma

A Prospective, Multicenter, Randomized Controlled Study to Compare Chemoradiotherapy With or Without Enteral Nutrition Intervention for Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 222 (actual)
• Sponsor: Sichuan Cancer Hospital and Research Institute · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

This is a randomized, prospective, multicenter study.

Detailed description

This is a randomized, prospective, multicenter study. The aim of this study was to compare the changes of body weight,survival,toxicity,quality of life and opportunistic infection frequency in Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma between and after chemoradiotherapy with or without enteral nutrition therapy.

Conditions

• Esophageal Squamous Cell Carcinoma
• Enteral Nutrition Therapy
• Chemoradiotherapy

Interventions

Type	Name	Description
DRUG	Enteral nutrition	Patients in the Trial Group received concurrent chemoradiotherapy and standardized, whole-course enteral nutrition management.
RADIATION	radiotherapy	Patients receive intensity modulated radiation therapy(IMRT) from week 1 to week 7,once a day, 5 times per week. Radiotherapy dose：95% gross tumor volume（GTV-T） 60-66 Gy /30-33f，GTV-N 60-66 Gy /30-33f，CTV-T 50-54 Gy /25-27f，CTV-N 50-54 Gy /25-27f.

Timeline

• Start date: 2014-09-01
• Primary completion: 2017-10-01
• Completion: 2017-10-01
• First posted: 2015-03-26
• Last updated: 2020-03-17

Locations

1 site across 1 country: China