NCT02399059

Effect of Peritoneal Lavage With Clindamycin-Gentamicin Solution & Oncologic Outcome

Effect of Peritoneal Lavage With Clindamycin-Gentamicin Solution During Elective Colorectal Cancer Surgery on the Oncologic Outcome

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 106 (actual)
• Sponsor: Hospital General Universitario Elche · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Antibiotic lavage reduces bacterial contamination and decreases SSI infection rate. SSI leads to an immunocompromised situation, leaving unattended the neoplasm. It has been described that SSI may result in a worse oncologic outcome.

Detailed description

Antibiotics combined with lavage have demonstrated a reduction in the bacterial contamination and decreases SSI infection rate. SSI leads to an immunocompromised situation, as immunologic defense is focused on controlling the septic focus, leaving unattended the neoplasm. It has been described that SSI may result in a worse oncologic outcome. The aim of this study is to evaluate prospectively the effect of peritoneal lavage with clindamycin and gentamicin on the oncologic outcome of colorectal tumours.

Conditions

• Colorectal Tumors

Interventions

Type	Name	Description
PROCEDURE	Antibiotic lavage	Peritoneal irrigation with gentamycin-clindamycin solution
PROCEDURE	Normal saline lavage	Peritoneal irrigation with normal saline

Timeline

• Start date: 2011-01-01
• Primary completion: 2015-03-01
• Completion: 2015-03-01
• First posted: 2015-03-26
• Last updated: 2015-03-26