NCT02397993

Serum Parameter Prior and After EUS-guided Fine Needle Aspiration of the Pancreas

Serum Lipase, Amylase and CA 19-9 Prior and After EUS-guided Fine Needle Aspiration of the Pancreas

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 208 (estimated)
• Sponsor: Helios Albert-Schweitzer-Klinik Northeim · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Endoscopic ultrasonography (EUS ) -guided fine needle aspiration (EUS -FNA ) of focal pancreatic lesions is an essential diagnostic procedure with high therapeutic effect in clinical routine. The aim of this study is to determine the levels of serum lipase, serum amylase and the tumor marker CA 19-9 prior and after EUS-FNA. In animal experiments on dogs, an increase of all three parameters was observed after surgery on the pancreas. For humans, these clinically important data are not yet available . It is assumed that the probability of pancreatitis with increased activity of lipase and amylase will rise with the number of puncture procedures as well as the size of the puncture needle. In addition, the post-interventional assessment of the tumor marker CA 19-9 could result in a false positive assumption of malignant neoplastic pancreatic lesion.

Conditions

• Pancreatitis

Interventions

Type	Name	Description
PROCEDURE	blood collection	blood will be taken for assessment of serum lipase, serum amylase and CA 19-9 prior to EUS-FNA
PROCEDURE	fine needle aspiration	During endoscopic ultrasonography, fine needle aspiration will be performed for cytological analysis of the pancreas
PROCEDURE	blood collection	blood will be taken 4h after EUS-FNA for assessment of serum lipase, serum amylase and CA 19-9

Timeline

• Start date: 2015-03-01
• Primary completion: 2019-12-01
• Completion: 2020-12-01
• First posted: 2015-03-25
• Last updated: 2019-02-12

Locations

3 sites across 1 country: Germany