NCT02396888

Effects of Local Insulin on Wound Angiogenesis

Effects of Local Insulin on Angiogenesis in Acute Wounds in Non-diabetic Patients

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Hospital Central "Dr. Ignacio Morones Prieto" · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Randomized, split plot, double-blind, placebo controlled trial. Half of the wounds surface was applied daily with insulin and the other half with saline solution as placebo. Biopsy specimens of the two sides were obtained on days 0 and 14. Number of blood vessels will be evaluated as main outcome.

Detailed description

Randomized, split plot, double-blind, placebo controlled trial. Non-diabetic patients with full-thickness wounds will be treated in the following manner: in half of the surface insulin will be applied in a daily basis, on the other half, saline solution will be used as placebo. Biopsy specimens of both sides will be obtained on days 0 and 14. Number of blood vessels will be evaluated as main outcome.

Conditions

• Angiogenesis

Interventions

Type	Name	Description
DRUG	Insulin	Half of the wound surface was treated daily with 10 units of intermediate insulin.
DRUG	Placebo	Half of the wound surface was treated daily with 0.1 cc of normal saline.

Timeline

• Start date: 2014-10-01
• Primary completion: 2015-04-01
• Completion: 2015-05-01
• First posted: 2015-03-24
• Last updated: 2015-03-24

Locations

1 site across 1 country: Mexico