Trials / Unknown
UnknownNCT02391792
Membrane Shedding During Severe Sepsis and Septic Shock: Pathophysiological and Clinical Relevance
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 300 (estimated)
- Sponsor
- University Hospital, Strasbourg, France · Academic / Other
- Sex
- All
- Age
- 18 Years – 85 Years
- Healthy volunteers
- Not accepted
Summary
Microparticules (MPs) result from plasma cell membrane remodeling and shedding after cell stimulation or apoptosis. MPs are know recognized as a pool of bioactive messengers with merging role in pathophysiology of immune and cardiovascular diseases. MPs have been characterized during septic shock and may contribute to dissemination of pro-inflammatory and procoagulant mediators. This a prospective observational study of circulating MPs and blood coagulation in septic shock patients admitted in medical intensive care units (ICUs) of four tertiary hospitals at baseline (D1, D2, D3, D4, D7).
Conditions
Timeline
- Start date
- 2013-03-01
- Primary completion
- 2020-03-01
- Completion
- 2020-03-01
- First posted
- 2015-03-18
- Last updated
- 2016-08-24
Locations
1 site across 1 country: France
Source: ClinicalTrials.gov record NCT02391792. Inclusion in this directory is not an endorsement.