NCT02391090

FeNO After Hypoxia in Asthma Patients

Effects of Intermittent Hypoxia on the Asthmatic Inflammation of Asthma Patients - a Pilot Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 21 (actual)
• Sponsor: Medical University of Graz · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Stable Asthma patients (GINA 1-2) stay 6 days in a row for 4 hours per day in a hypoxic chamber simulating 2800m above sea level. Study participants will be blinded to the treatment given and divided into a hypoxic and a sham group (about 360m above sea level). Effects of this intermittent hypoxia on the asthmatic inflammation of these patients will be measured. The primary endpoint is the change in forced exhaled nitric oxide (FeNO) before and after the study. Secondary endpoints include blood parameters, lung function testing and questionnaires.

Conditions

• Asthma

Interventions

Type	Name	Description
DEVICE	hypoxia in hypoxic chamber	Intervention lasts 4 hours per day for 6 days in a row.
DEVICE	sham hypoxia in hypoxic chamber	Intervention lasts 4 hours per day for 6 days in a row.
PROCEDURE	Pulse oximetry	Pulse oximetry will be performed hourly during sessions in the hypoxic chamber for safety reasons.
OTHER	Asthma and Quality of Life Questionnaires	Before every session in the hypoxic chamber as well as on the day after the last session will be completed.
PROCEDURE	Lung function testing	On the day of the first session in the hypoxic chamber as well as on the day after the last session lung function testing will be performed.
PROCEDURE	Blood taking	On the day of the first session in the hypoxic chamber as well as on the day after the last session blood samples will be taken.
PROCEDURE	FeNO measurement	Before every session in the hypoxic chamber as well as on the day after the last session FeNO (forced exhaled nitric oxide) measurement will be performed.

Timeline

• Start date: 2014-11-01
• Primary completion: 2015-03-01
• Completion: 2015-03-01
• First posted: 2015-03-18
• Last updated: 2015-03-18

Locations

1 site across 1 country: Austria