NCT02389335

Roles of T Helper 1 Cytokines in Type 1 Diabetes

Roles of Interferon Gamma, Interleukin-2 and Tumor Necrotizan Factor Alpha in the Pathogenesis of Type 1 Diabetes

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 128 (actual)
• Sponsor: Istanbul Medeniyet University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

The mechanism of β cell destruction in Type 1 diabetes is not exactly known, Our hyphotesis is that interferon gamma, interleukin-2 and tumor necrotizan factor alpha have impotant roles in β cell destruction.

Detailed description

T helper (h)1 cells are known to have important roles in the destruction or/and dedifferentiation of β-cells in type 1 diabetes (T1D). Significant increase in IFN-γ-producing Th1 cells in the pancreas and in the serum levels were determined in type 1 diabetic patients at diabetes oneset. This data indicated that this proinflammatory mediator serve as a biomarker of advanced autoimmunity. We aimed to investigate the relationship between Th1 cytokines (IFN-γ, IL-2 and TNF-α) and T1D and the effect of those cytokines on β-cell function.

Conditions

• Type 1 Diabetes

Timeline

• Start date: 2013-04-01
• Primary completion: 2014-07-01
• Completion: 2014-11-01
• First posted: 2015-03-17
• Last updated: 2015-03-17

Locations

1 site across 1 country: Turkey (Türkiye)