NCT02389075

The Colonic Microbiome and Mucosal Immunity in Inflammatory Bowel Disease and Ankylosing Spondylitis

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 129 (actual)
• Sponsor: University of Colorado, Denver · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

This study plans to learn more about the relationship between systemic autoimmune disease, such as inflammatory bowel disease and ankylosing spondyloarthritis, bacteria in the colon, and the changes in colon tissue.

Detailed description

Changes in human gut bacteria has been shown in patients with autoimmune diseases, such as inflammatory bowel diseases (IBD). The gut flora in ankylosing spondylitis (AS), an arthritis that can occur with IBD, has not been well studied. The immune cells in the colon directly interface with bacteria and may be influenced by them. The interactions between the colon immune system, bacteria and autoimmunity hasn't been studied. The study goal is to specifically study the link between bacteria, the colonic immune system, and the autoimmune diseases of AS and IBD. This will be done by collecting clinical data by questionnaires, blood samples, colonic tissue during endoscopy, and microbiome data in subjects with IBD, AS, and controls.

Conditions

• Inflammatory Bowel Diseases (IBD)
• Ankylosing Spondylitis (AS)

Interventions

Type	Name	Description
PROCEDURE	Pinch biopsies	Biopsies obtained during colonoscopy or flexible sigmoidoscopy.
PROCEDURE	Flexible sigmoidoscopy	Offered to subjects with ankylosing spondylitis who do not meet criteria for colonoscopy

Timeline

• Start date: 2015-03-01
• Primary completion: 2026-10-01
• Completion: 2026-10-01
• First posted: 2015-03-17
• Last updated: 2024-05-21

Locations

1 site across 1 country: United States