NCT02388802

Human Clinical Trial of Uterine Transplantation in the United Kingdom

The First Human Clinical Trial of Uterine Transplantation in the United Kingdom

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (estimated)
• Sponsor: Womb Transplant UK · Academic / Other
• Sex: Female
• Age: 18 Years – 36 Years
• Healthy volunteers: Not accepted

Summary

Ten patients will undergo uterine transplantation.

Detailed description

Ten patients that will be appropriately selected using a variety of physical and psychological assessments. The selected patients will undergo egg retrieval and subsequent freezing of embryos to enable IVF treatment following transplantation. Following uterine transplantation, using deceased donor allografts, the patients will be closely monitored for 12 months clinically, radiologically and immunologically until embryo transfer. Following successful embryo transfer the patients will continue to be monitored antenatally until they are delivered by Caesarean section.

Conditions

• Infertility

Interventions

Type	Name	Description
PROCEDURE	Oocyte retrieval and freezing	10 Patients will undergo oocyte retrieval and freezing
PROCEDURE	Deceased Donor Allograft Excision	Appropriately matched uterine transplant allografts will be excised from deceased donors
PROCEDURE	Uterine Transplantation	Following egg freezing the patients will undergo uterine transplant from deceased donors
DRUG	Immunosuppressive Agents	Patients will be appropriately immunosuppressed, whilst being closely monitored clinically, radiologically and immunologically.
PROCEDURE	In-vitro fertilisation	12 months after successful transplantation,the patients will undergo IVF
PROCEDURE	Caesarean Section	Following successful conception and antenatal period, the babies will be born by Caesarean Section

Timeline

• Start date: 2017-01-01
• Primary completion: 2020-01-01
• Completion: 2020-01-01
• First posted: 2015-03-17
• Last updated: 2016-11-08