NCT02388477

Trial of the Use of Doxycycline After Rotator Cuff Repair

Randomized Controlled Trial of the Use of Doxycycline After Rotator Cuff Repair

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Milton S. Hershey Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to examine healing after rotator cuff repair in subjects either treated with Doxycycline or placebo post-operatively.

Detailed description

Basic Science small animal model data indicates that matrix metalloproteinase (MMP) inhibition via doxycycline results in improved early rotator cuff repair biomechanics and histology. Rotator cuff repair failure and retear is a significant clinical problem. The effects of MMP inhibition on human rotator cuff tear repair healing and outcomes is unknown, but may potentially improve healing rates and outcomes. Our purpose is to evaluate the effects of early oral doxycycline on healing and outcomes following arthroscopic rotator cuff repair.

Conditions

• Rotator Cuff Injury

Interventions

Type	Name	Description
DRUG	Doxycycline	antibiotic used to treat infection
DRUG	sugar pill	placebo with no pharmacologic effect

Timeline

• Primary completion: 2016-05-01
• First posted: 2015-03-17
• Last updated: 2016-05-09

Locations

1 site across 1 country: United States