NCT02387398

Early Coronary Angiography Versus Delayed Coronary Angiography

A Pilot Randomized Clinical Trial of Early Coronary Angiography Versus No Early Coronary Angiography for Post-Cardiac Arrest Patients Without ECG ST Segment Elevation

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 99 (actual)
• Sponsor: University of Arizona · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study is a pilot, multi-centered, randomized, clinical trial to evaluate the safety and efficacy of performing early Coronary Angiography (CAG) versus no early CAG in post-cardiac arrest patients without ST segment elevation. Safety will be assessed by evaluating the association of major adverse events (re-arrest, bleeding, pulmonary edema, hypotension, acute renal insufficiency, and pneumonia) with early coronary angiogram. Efficacy will be assessed by a composite endpoint of improved left ventricular regional and global function (both regional wall motion analysis and left ventricular ejection fraction) as measured by echocardiography prior to hospital discharge and favourable neurological function (Cerebral Performance Categories 1 or 2) at discharge.

Detailed description

Cardiac arrest is a major public health issue. Arizona has been a leader in improving long-term survival by introducing new and innovative resuscitation approaches including "Chest Compression-Only CPR" and "Cardiocerebral Resuscitation". Post-resuscitation care is the next great opportunity for further improvements. Early coronary angiography (CAG) combined with therapeutic hypothermia has become the recommended standard of care for post-cardiac arrest patients manifesting ST segment elevation on their electrocardiogram (ECG). However, the majority of cardiac arrest victims do not have ST segment elevation. There is clinical equipoise as to whether these patients will benefit from early CAG. Subjects who are qualified for the study will be randomized 1:1 to one of two groups. ° Intervention Group-Early coronary angiography (door-to-angiography) within 120 minutes of admission to Emergency Department. or ° Control Group-No early coronary angiography (within the first six hours from admission) All enrolled patients, will be treated with therapeutic hypothermia which is standard of care, beginning simultaneously with both groups or within at least 2 hours of hospital arrival. Subject will be followed for 180 days for safety and long-term survival.

Conditions

• Out-of-Hospital Cardiac Arrest
• Hypothermia
• Cardiac Arrest

Interventions

Type	Name	Description
PROCEDURE	Early Angiography	Coronary Angiography within 120 minutes of admission for out-of-hospital cardiac arrest with ROSC

Timeline

• Start date: 2016-01-01
• Primary completion: 2018-10-31
• Completion: 2019-04-30
• First posted: 2015-03-13
• Last updated: 2022-01-14

Locations

6 sites across 3 countries: United States, Australia, Slovenia