Trials / Unknown
UnknownNCT02383797
Immunodeficiency in Cartilage-hair Hypoplasia: Sub-project on Safety of Vaccination Against Chickenpox
Immunodeficiency in Cartilage-hair Hypoplasia: Correlation With Pulmonary Disease, Infections and Malignancy
- Status
- Unknown
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 5 (actual)
- Sponsor
- Helsinki University Central Hospital · Academic / Other
- Sex
- All
- Age
- 12 Months
- Healthy volunteers
- Not accepted
Summary
The investigatoris will carefully select cartilage-hair hypoplasia patients unexposed to varicella (VZV) and immunize patients in a controlled manner with VZV vaccine. Patients will be selected on the basis of disease severity and the degree of immunodeficiency (including CD4+ T-cell counts). Any potential complication of VZV immunization, such as rash, will be discussed with the patients/caregivers beforehand and acyclovir will be used to treat any VZV related symptoms, consistent with the current practices. The investigators will verify the development of immune response to vaccination by testing for VZV antibodies and cell-mediated immunity.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| BIOLOGICAL | Varilrix | Vaccination against varicella in selected cartilage-hair hypoplasia patients |
Timeline
- Start date
- 2015-02-01
- Primary completion
- 2019-10-01
- Completion
- 2020-02-01
- First posted
- 2015-03-09
- Last updated
- 2019-10-22
Source: ClinicalTrials.gov record NCT02383797. Inclusion in this directory is not an endorsement.