NCT02382354

Remifentanil for the I-gel and Laryngeal Mask Airway Insertion

Comparison of the Effect-site Concentration of Remifentanil for Insertion of the I-gel and Laryngeal Mask Airway During Propofol Anesthesia

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 41 (actual)
• Sponsor: Ajou University School of Medicine · Academic / Other
• Sex: Female
• Age: 19 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Structural differences of supraglottic airway devices could influence the different compressive forces in the oropharyngeal cavities, and require different depth of anesthesia. The addition of remifentanil during propofol anesthesia facilitates the insertion of laryngeal mask airway (LMA) with minimal adverse hemodynamic disturbances. This study was designed to determine the effect-site concentration of remifentanil in 50% of patients (EC50) and 95% of patients (EC95) for successful i- gel insertion, and compare those for LMA insertion during propofol target-controlled infusion (TCI).

Detailed description

Anesthesia was induced with propofol TCI at the effect-site concentration of 5 μg/ml, and the predetermined effect-site concentration of remifentanil was started simultaneously. The remifentanil concentration was determined using modified Dixon's up-and-down method (initial concentration: 3.0 ng/ml, step size: 0.5 ng/ml). Five minutes later, i- gel or LMA insertion was attempted. The response of the patients to the insertion of LMA was classified as either 'movement' or 'no movement'.

Conditions

• Supraglottic Airways for General Anesthesia

Interventions

Type	Name	Description
DRUG	remifentanil	The predetermined effect-site concentration of remifentanil was started using modified Dixon's up-and-down method
DEVICE	i-gel	I-gel insertion was inserted 5 min after anesthesia induction
DEVICE	laryngeal mask airway	laryngeal mask airway insertion was inserted 5 min after anesthesia induction
DRUG	propofol	Anesthesia was induced with propofol target-controlled infusion at the effect-site concentration of 5 μg/ml

Timeline

• Start date: 2015-03-01
• Primary completion: 2015-09-01
• Completion: 2015-09-01
• First posted: 2015-03-06
• Last updated: 2015-10-14

Locations

1 site across 1 country: South Korea