NCT02376270

Pectin, Aging and Intestinal Barrier Function

The Effects of Pectin on Aging-related Changes in Intestinal Barrier Function, Immune Function and Microbial Composition

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: Maastricht University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

The population is aging worldwide, which requires more attention to health needs and leads to a dramatic increase in health care costs. Prevention or delay of onset of disorders associated with aging is needed. Dietary intake of pectin, a dietary fiber, may have beneficial effects on gut health parameters, i.e. intestinal barrier function, immune function and microbial composition. As intestinal barrier function may be compromised in the elderly we will investigate whether the effects of pectin on selected parameters of gut health differ between young vs. older individuals. The primary objective of this study is to investigate the effects of aging on pectin-induced changes in intestinal permeability. Furthermore, this study has seven secondary objectives. This study conforms to a randomized, double-blind and placebo-controlled design including two parallel arms.The study population consists of Healthy human volunteers (male and female), 18-40 and 65-75 years old, BMI 20-30 kg/m2. One group will receive 7.5 grams of pectin supplements twice daily for four weeks. A second group will receive 7.5 grams of placebo supplements twice daily for four weeks. Before and after the supplementation period, several measurements will take place. The main study parameter is the change in urinary sugar excretion ratio before and after the intervention period.

Conditions

• Healthy Young Adults
• Healthy Elderly

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Pectin	This group will receive 7.5 grams of pectin supplements twice daily for four weeks.
DIETARY_SUPPLEMENT	Maltodextrin	This group will receive 7.5 grams of maltodextrin supplements twice daily for four weeks.

Timeline

• Start date: 2015-03-01
• Primary completion: 2016-05-01
• Completion: 2016-05-01
• First posted: 2015-03-03
• Last updated: 2016-07-15

Locations

1 site across 1 country: Netherlands