NCT02374593

Targeted Levothyroxine Dosing in Infants With Congenital Hypothyroidism

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Erica Eugster · Academic / Other
• Sex: All
• Age: 2 Weeks
• Healthy volunteers: Not accepted

Summary

This is a clinical study comparing targeted levothyroxine dosing based on thyroid anatomy as visualized on ultrasound (normal vs. ectopic/sublingual vs. athyreosis) to empiric levothyroxine dosing in infants with congenital hypothyroidism. Patients enrolled in the study for targeted dosing will be compared to controls obtained by retrospective chart review. The main outcome is to determine if there is a difference in the frequency of over-treatment and under-treatment during the first 6 months of therapy.

Conditions

• Congenital Hypothyroidism

Interventions

Type	Name	Description
DRUG	Levothyroxine	Levothyroxine dose will be adjusted at the first clinic visit based on thyroid anatomy on ultrasound.
DEVICE	Ultrasound

Timeline

• Start date: 2014-03-01
• Primary completion: 2016-05-01
• Completion: 2016-05-01
• First posted: 2015-03-02
• Last updated: 2017-10-09
• Results posted: 2017-10-09

Locations

1 site across 1 country: United States