NCT02373735

Effect of SVV Guided Fluid Therapy on Blood Loss and Postoperative Outcomes

Effect of Stroke Volume Variation Guided Fluid Therapy on the Blood Loss and Postoperative Outcomes in Radical Cystectomy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 64 (actual)
• Sponsor: Asan Medical Center · Academic / Other
• Sex: All
• Age: 20 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to investigate the effect of stroke volume variation (SVV) guided fluid therapy on the blood loss and postoperative outcomes in radical cystectomy.

Detailed description

The purpose of this study is to investigate the effect of stroke volume variation(SVV) guided fluid therapy on the blood loss and postoperative outcomes in radical cystectomy. Patients were randomized to fluid management to maintain \<10% SVV (group A), or to undergo fluid management during radical cystectomy to maintain SVV 10-20% (group B). Intraoperative blood loss and hemodynamic parameters, perioperative laboratory data, and postoperative complications were compared between two groups.

Conditions

• Bladder Cancer

Interventions

Type	Name	Description
OTHER	crystalloid	Group A (SVV \<10%): infuse crystalloid 6-10 ml/kg/hr during surgery. Group B (SVV 10-20%): infuse crystalloid 2-4 ml/kg/hr until cystectomy, 6-10 ml/kg/hr after cystectomy
OTHER	colloid	Group A (SVV \<10%): infuse colloid 200 ml if SVV is ≥ 10%. Group B (SVV 10-20%): infuse colloid 200 ml if SVV is \> 20%
OTHER	mannitol	Group B (SVV 10-20%): infuse mannitol 0.5 g/kg if SVV is \< 10%
OTHER	lasix	Group B (SVV 10-20%): infuse lasix 5 mg if SVV is \< 10%

Timeline

• Start date: 2015-03-01
• Primary completion: 2015-11-01
• Completion: 2015-12-01
• First posted: 2015-02-27
• Last updated: 2015-12-30

Locations

1 site across 1 country: South Korea