NCT02373163

INTERVENCION Trial

Characterization of Arterial Hypertension and Efficacy of Blood-pressure Lowering Therapy at Different Altitudes Above Sea Level

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 166 (actual)
• Sponsor: Prevencion · Academic / Other
• Sex: All
• Age: 50 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This trial is designed to: 1. Assess the response to montherapy with : a thiazide diuretic (HCTZ), a calcium-channel blocker (CCB, amlodipine) and an angiotensin-receptor blocker (telmisartan), among hypertensive subjects who live at sea level, at medium altitude above sea level and at high altitude above sea level. 2. To test whether diferentes exist in the response to therapy among subjects who live at different altitude above sea level 3. To assess the hemodynamic characteristics of hypertension in populations that live at sea level, at medium altitude above sea level, and at high altitude above sea level.

Conditions

• Blood Pressure, High

Interventions

Type	Name	Description
DRUG	Hydrochlorothiazide	Arm: Active Comparator: Diuretic Therapy with hydrochlorothiazide (25 mg daily) taken once daily between 6 and 8 AM Arm: Active Comparator: Calcium-channel blocker Therapy with amlodipine (10 mg daily) taken once daily between 6 and 8 AM Arm: Active Comparator: Angiotensin Receptor Blocker Therapy with Telmisartan (80 mg daily) taken once daily between 6 and 8 AM
DRUG	Amlodipine	Therapy with amlodipine (10 mg daily) taken once daily between 6 and 8 AM
DRUG	Telmisartan	Therapy with Telmisartan (80 mg daily) taken once daily between 6 and 8 AM

Timeline

• Start date: 2014-09-01
• Primary completion: 2016-03-01
• Completion: 2016-06-01
• First posted: 2015-02-26
• Last updated: 2025-07-29
• Results posted: 2025-07-29

Locations

1 site across 1 country: Peru