NCT02373033

Folate-Rich Foods Improve Folate Status

The Effects of a 3-months Dietary Intervention With Folate Enhanced Foods on Folate Status in Healthy Egyptian Women

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 57 (actual)
• Sponsor: Mansoura University · Academic / Other
• Sex: Female
• Age: 19 Years – 32 Years
• Healthy volunteers: Accepted

Summary

This study evaluates the effects of folate-rich foods regarding improvement of folate status compared with folic acid supplement. A randomized, parallel intervention trial with two active groups (folate-rich foods or folic acid supplement) and one control group (apple juice - 0 µg/d folate) was executed over 12 weeks.

Detailed description

Sixty-two women in reproductive age, apparently healthy, non-smokers, not consuming special diets (vegetarian), not pregnant, not planning conception or not lactating. A randomized, controlled, parallel intervention trial with two active groups and one blinded control group was carried out for 12 weeks (March to June, 2013). The active food group (n = 21) consumed folate-rich foods (germinated canned faba beans, cookies, orange juice, providing additional 250 μg/d folate); the active folic acid supplement group consumed a supplement (n = 19, providing 500 μg/d folic acid); and the control group (n = 22) received apple juice containing no folate or folic acid) in addition to the freely chosen diet. Fasted venous blood samples were collected at baseline, two months and three months for quantification of folate in plasma and erythrocytes and of homocysteine in plasma.

Conditions

• Folic Acid Deficiency

Interventions

Type	Name	Description
OTHER	Natural food folate	Consumed folate-rich foods (providing additional 250 μg/d folate).
OTHER	Folic acid	Received a folic acid supplement (providing additional 500 μg/d folic acid).
OTHER	Apple juice	Received apple juice containing no folate or folic acid.

Timeline

• Start date: 2013-03-01
• Primary completion: 2013-06-01
• Completion: 2013-06-01
• First posted: 2015-02-26
• Last updated: 2015-02-26

Locations

1 site across 1 country: Egypt