NCT02369614

Low -vs- High-Frequency Repetitive TMS of the Right Dorsolateral Prefrontal Cortex in PTSD

Low-Frequency Versus High-Frequency Repetitive Transcranial Magnetic Stimulation of the Right Dorsolateral Prefrontal Cortex in Posttraumatic Stress Disorder

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: United States Naval Medical Center, San Diego · Federal
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This is a randomized placebo/sham controlled, double-blind study investigating the efficacy of high- and low-frequency rTMS applied to the right DLPFC at either 1 Hz, 10 Hz, or sham rTMS as compared to an OASIS treatment as usual group for the treatment of PTSD symptoms.

Detailed description

The study will be carried out within the Overcoming Adversity and Stress Injury Support (OASIS) program administered by Naval Medical Center San Diego (NMSD). OASIS is a residential treatment program developed for active duty service members diagnosed with combat related PTSD. OASIS is a 9 week program in which cohorts of 10 patients undergo a variety of therapeutic activities with a focus on cognitive processing therapy (CPT) of combat trauma conducted in both group and individual formats. Subjects who qualify will be assigned by block randomization to one of four arms: 1. 1 Hz rTMS of the right dorsolateral prefrontal cortex 2. 10 Hz rTMS of the right dorsolateral prefrontal cortex 3. Sham rTMS of the right dorsolateral prefrontal cortex 4. OASIS treatment as usual Treatment will be administered in 10 daily sessions, conducted on weekdays, for 2 consecutive weeks. .

Conditions

• PTSD - Post Traumatic Stress Disorder

Interventions

Type	Name	Description
OTHER	Active Comparator: 1 Hz rTMS	1 Hz rTMS
OTHER	Active Comparator: 10 Hz rTMS	10 Hz rTMS
OTHER	Sham Comparator:	Sham rTMS

Timeline

• Start date: 2014-08-01
• Primary completion: 2019-03-01
• Completion: 2019-03-01
• First posted: 2015-02-24
• Last updated: 2019-03-14