NCT02368704

Role of Endoplasmic Reticulum Stress in the Pathophysiology of Type 2 Diabetes

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 40 (actual)
• Sponsor: Assistance Publique - Hôpitaux de Paris · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to investigate whether Endoplasmic Reticulum (ER) stress pathway is activated in peripheral tissues (adipose tissue) in insulin resistant diabetic patients compared to healthy subjects normoglycemic matched for age and sex an to investigate whether ER stress pathway can be activated in response to insulin. Indeed, some preliminar on rates studies shows that ER stress pathway is activated by insulin in liver and adipose tissue showing that hyperinsulinemia might help trigger stress path ER. For this, we propose a case control study of type 2 diabetic patients vs control subjects in which markers of ER stress will be evaluated from abdominal subcutaneous adipose tissue obtained before and after euglycemic hyperinsulinemic. We chose to consider adipose tissue subcutaneous rather than visceral adipose tissue for obvious reasons of lesser invasiveness.

Conditions

• Diabetes Mellitus, Type 2
• Endoplasmic Reticulum Stress

Interventions

Type	Name	Description
OTHER	No intervention

Timeline

• Start date: 2012-11-01
• Primary completion: 2016-11-01
• Completion: 2016-11-01
• First posted: 2015-02-23
• Last updated: 2016-04-18

Locations

1 site across 1 country: France