NCT02364661

The Influence of Short-term Starvation on Hepatitis B Virus Load

The Influence of Short-term Starvation on Disease Severity and Viral Replication Among Hepatitis B Virus Patients

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Rabin Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Hepatitis B virus is a small DNA virus that affects 400 million people worldwide. The virus infects the liver and previous studies, done in tissue culture and in animals, have shown that viral replication is affected by metabolic changes occurring in the liver. Specifically, starvation induces HBV gene expression and replication, in parallel to the activation of the gluconeogenesis response, and feeding attenuates viral activity. In this study we are going to recruit HBV patients with detectable viremia and analyze their viral load after an over night starvation versus after a morning meal. Our hypothesis is that following an over-night starvation viral load will be higher than that in the fed state.

Conditions

• Starvation
• Infection

Interventions

Type	Name	Description
BEHAVIORAL	Over night starvation (fasting)	HBV viral load will be analyzed after over-night starvation versus following a morning meal

Timeline

• Start date: 2015-03-01
• Primary completion: 2016-03-01
• First posted: 2015-02-18
• Last updated: 2015-02-18