NCT02363725

Interest of COLchicine in the Treatment of Patients With Acute Myocardial INfarction and With Inflammatory Response

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 44 (actual)
• Sponsor: University Hospital, Montpellier · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

Background: Colchicine is an old well-known venerable drug routinely used in gout attacks for instance. More recnetly it is regularly use in the treatment of pericarditis. It couls exert antiiflammatory effects targeting the adverse inflammation occuring incase of acute myocardial infarction, which is involved in poor outcomes or longer stay at hospital. Endpoints: * Main endpoint: AUC CRP during the initial hospital stay * Secondary endpoints: * Clinical: oucomes * Imaging: ETT, MRI * Biological: various biomarkers Method Randomized, controled, open-labbelled, comparing two parallel arms: conventionnal optimal treatment versus conventionnal optimal treatment + colchicine

Conditions

• Acute Myocardial Infarction

Interventions

Type	Name	Description
DRUG	Colchimax®
DRUG	Conventional treatment

Timeline

• Start date: 2014-12-01
• Primary completion: 2016-05-01
• Completion: 2016-08-01
• First posted: 2015-02-16
• Last updated: 2017-01-18

Locations

1 site across 1 country: France