NCT02361827

The Effect of Vitamin D on in Vitro Fertilization Outcome

The Effect of Vitamin D on in Vitro Fertilization Outcome, a Prospective Observational Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 688 (actual)
• Sponsor: The First Affiliated Hospital of Zhengzhou University · Academic / Other
• Sex: Female
• Age: 21 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

To date, several studies have been done to explore the relationship between Vitamin D level and IVF outcome; however, the results are controversial. Sample sizes in these studies mentioned above were relatively small. In addition, there are no prospective cohort studies in this field. Thus, here the investigators carry this prospective observational cohort study to demonstrate the relationship between vitamin D level and IVF outcome.

Detailed description

Vitamin D level is measured before the commence of IVF cycle. According to Vitamin D level, patients are divided into 3 groups: A, Deficient, \<20 ng/mL; B, Insufficient, 20-29.9 ng/mL; C, Replete, \>30 ng/mL. Ongoing pregnancy rate are compared among these three groups after controlling age, number of embryos transferred, ect. In addition, Vitamin D level is also meassured before embryo transfer in FET cycles with PGT treatment. The effect of Vitamin D on IVF outcome is detected in patients transferred with Euploid embryos.

Conditions

• Ongoing Pregnancy Rate
• Vitamin D
• In Vitro Fertilization

Interventions

Type	Name	Description
PROCEDURE	Embryo transfer	For patients in each group after oocyte retrieval, they will have embryo transferred 3 or 5 days after oocyte retrieval. For FET cycles, they will have ET with an euploid blastocyst.

Timeline

• Start date: 2018-01-01
• Primary completion: 2022-09-01
• Completion: 2024-12-01
• First posted: 2015-02-12
• Last updated: 2025-03-05

Locations

1 site across 1 country: China