NCT02361190

Effects of Fast Acting Testosterone Nasal Spray on Anxiety

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 96 (actual)
• Sponsor: University of Texas at Austin · Academic / Other
• Sex: Male
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The proposed study will test the effects of a fast-acting testosterone nasal spray on the fear reactions of young men to two distinct anxiety challenges (social and nonsocial) using a double-blind randomized experimental design.

Detailed description

Aim 1: Test the hypothesis that men administered testosterone nasal spray will result in lower levels of anxiety (anticipatory and situational) and greater levels of approach behavior in response to two distinct (social and nonsocial) anxiety challenges relative to men administered placebo spray. Aim 2: Test the hypothesis that anxiety challenge type (social versus nonsocial) will moderate the effects of testosterone administration on subjects' responses to challenge. Aim 3: Test the hypothesis that rejection sensitivity - heightened sensitivity to evaluative threat - will moderate the effects of drug condition on response to the two anxiety challenge tests.

Conditions

• Anxiety

Interventions

Type	Name	Description
DRUG	Testosterone	Administration of 1ml aqueous nasal spray containing 7mg testosterone propionate
DRUG	Placebo	Administration of 1ml aqueous saline spray

Timeline

• Start date: 2015-02-01
• Primary completion: 2016-04-01
• Completion: 2016-05-01
• First posted: 2015-02-11
• Last updated: 2021-04-28

Locations

1 site across 1 country: United States