NCT02360683

Predictive Factors and Subthalamic Stimulation in Parkinson's Disease

Predictive Factors for Therapeutic Response of Subthalamic Stimulation on Quality of Live in Parkinson's Disease

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 700 (actual)
• Sponsor: University Hospital, Lille · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

This study identify preoperative predictors of response to subthalamic stimulation at 1 year, 3 years and 5 years in terms of quality of life, from a broad prospective multicenter study French with standardized collection of clinical data , imaging and genetic . The investigators want to identify factors that predict the improvement of quality of life for one year corresponding to a decrease of PDQ39 score of at least 20 %. They believe that improvement would be less likely to become zero to 3 or 5 years and question the indication of the subthalamic stimulation (risks and costs). This is part of a process of "personalization" of the therapeutic care that is of any interest to the subthalamic stimulation. It is a therapeutic option that could be dangerous if patient selection is not optimal , and expensive, if the benefit is not large enough to reduce the number of medications and hospitalizations medium term . In addition, it will quantify the improvement of quality of life in the longer term and harmonize national assessments .

Conditions

• Parkinson's Disease

Interventions

Type	Name	Description
OTHER	patients with Parkinson's disease

Timeline

• Start date: 2013-11-18
• Primary completion: 2019-11-01
• Completion: 2025-11-01
• First posted: 2015-02-10
• Last updated: 2022-11-07

Locations

15 sites across 1 country: France