NCT02357550

Ketones Influence on Glucose Metabolism in Brain. A Human Positron Emission Tomography (PET) Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 9 (actual)
• Sponsor: University of Aarhus · Academic / Other
• Sex: All
• Age: 50 Years – 70 Years
• Healthy volunteers: Accepted

Summary

This project tend to investigate the affection of ketone bodies on brain metabolism. This will be done by measuring human cerebral uptake of energy substrates, together with functional parameters, using PET imaging and appropriate radiotracers under hyperketonemia in healthy subjects by ketone infusion. Hypotheses 1. Increased levels of ketone bodies in healthy subjects leads to decreased glucose uptake by brain cells contributing to hyperglycaemia. 2. Increased levels of ketone bodies in healthy subjects leads to increased cerebral blood flow. 3. Altered oxygen consumption during hyperketonemia in healthy subjects.

Conditions

• Ketone Body Metabolism
• Brain Metabolism

Interventions

Type	Name	Description
DRUG	ketone	3-OHB is infused intravenously.
DRUG	placebo	Saline infusion.

Timeline

• Start date: 2015-03-01
• Primary completion: 2016-01-01
• Completion: 2016-01-01
• First posted: 2015-02-06
• Last updated: 2016-01-18

Locations

1 site across 1 country: Denmark