NCT02357004

Mechanisms of Refractory Hypertension (Carvedilol)

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: University of Alabama at Birmingham · Academic / Other
• Sex: All
• Age: 19 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this protocol is test whether patients with hypertension refractory to antihypertensive treatment have evidence of excessive sympathetic (i.e., nervous system) activity.

Detailed description

Refractory hypertension refers to high blood pressure that is failing conventional antihypertensive therapies. In a retrospective assessment of such patients in our clinic we observed that resting clinic heart rates were higher in patients with refractory hypertension compared to patients with controlled hypertension. This observation has led to the hypothesis that refractory hypertension is caused by excessive sympathetic output. This protocol is designed to test this hypothesis by comparing the BP response to carvedilol verses chlorthalidone in patients with refractory hypertension. If their extreme treatment resistance is neurogenic is etiology, a significantly larger BP response to carvedilol should occur compared to chlorthalidone.

Conditions

• Hypertensive

Interventions

Type	Name	Description
DRUG	Carvedilol	CR 40 mg daily in addition to normal BP medications
DRUG	Chlorthalidone	12.5 mg daily in addition to normal BP medications

Timeline

• Start date: 2015-02-01
• Primary completion: 2020-01-31
• Completion: 2020-01-31
• First posted: 2015-02-06
• Last updated: 2020-06-12