Trials / Completed
CompletedNCT02348229
Effect of Enhanced Recovery After Surgery (ERAS) on C-reactive and Visceral Proteins
Effect of Enhanced Recovery After Surgery (ERAS) on C-reactive and Visceral Proteins in Patients With Advanced Gastric Cancer
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 149 (actual)
- Sponsor
- The First Hospital of Jilin University · Academic / Other
- Sex
- All
- Age
- 18 Years – 75 Years
- Healthy volunteers
- Not accepted
Summary
The investigators designed a prospective randomized, controlled clinical trial then recruited 149 consecutive advanced gastric cancer patients. Further divided into a ERAS group (n=73) and a conventional pathway group (n=76). Surgical technique in both groups was same laparoscopic-assisted gastrectomy with D2 lymphadenectomy. Compared outcomes included clinical parameters and serum indicators.
Detailed description
Enhanced recovery after surgery combined with laparoscopic-assisted gastrectomy was successfully carried out in this study. Recovery parameters such as the length of time to return to normal diet,mean hospital stay (d) were recorded.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | ERAS protocols | Normal meal allowed until 6 h before surgery and Carbohydrate drink until 2 h before surgery |
| PROCEDURE | ERAS protocols | No bowel preparation |
| PROCEDURE | ERAS protocols | No nasogastric placement; if used, remove on the 1st postoperative day |
| PROCEDURE | ERAS protocols | Vasoactive drugs used if need be |
| PROCEDURE | ERAS protocols | Temperature management |
| PROCEDURE | ERAS protocols | Intra-abdominal drains not to be used |
| PROCEDURE | ERAS protocols | Intraperitoneal Ropivicaine infusion |
| PROCEDURE | ERAS protocols | On the 1st postoperative day Nasogastric catheter removed /Urinary catheter removed. Oral non-opioid analgesia/Drinking 0.5L liquid. Active mobilisation |
| PROCEDURE | ERAS protocols | On the 2nd postoperative day：Drains removed Oral diet was initiated |
| PROCEDURE | ERAS protocols | 3-4th postoperative day： Stop oral non opioid analgesia |
| PROCEDURE | ERAS protocols | On the5-6th postoperative day Check discharge criteria |
| PROCEDURE | conventional pathway group | No solid foods at dinner before surgery and no liquids 12 h before surgery. Routine bowel preparation Nasogastric placement on the morning of surgery |
| PROCEDURE | conventional pathway group | Routine use of anesthesia medicine. Standard 5-trocar laparoscopy-assisted procedure. I.V. fluids not restricted (Ringer's lactate 20 ml/kg in the first hour, then at the rate of 10-12 ml/kg/h) Routine use of abdominal drainage tubes and placement of catheters. |
| PROCEDURE | conventional pathway group | 1st postoperative day: Keep Nasogastric catheter Removal of urinary catheter Opioid analgesic by intramuscular injection Parenteral nutrition until flatus. I.V. fluids not restricted Mobilization in bed |
| PROCEDURE | conventional pathway group | 2nd postoperative day Patient is advised to get out of bed until 24-48h after surgery |
| PROCEDURE | conventional pathway group | 3-4th postoperative day： Remove nasogastric tube after flatus Oral liquids started. Encouraged to walk in the ward. |
| PROCEDURE | conventional pathway group | 5-6th postoperative day：Oral diet was changed from liquids to semi-fluids and normal food. Drains removed |
Timeline
- Start date
- 2013-09-01
- Primary completion
- 2014-09-01
- Completion
- 2014-10-01
- First posted
- 2015-01-28
- Last updated
- 2015-01-28
Source: ClinicalTrials.gov record NCT02348229. Inclusion in this directory is not an endorsement.