NCT02347215

Changes in Ischemia and Angina Over 1 Year Among ISCHEMIA Trial Screen Failures With no Obstructive CAD on Coronary CT Angiography

Changes in Ischemia and Angina Over One Year Among ISCHEMIA Trial Screen Failures

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 212 (actual)
• Sponsor: NYU Langone Health · Academic / Other
• Sex: All
• Age: 21 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

Serial assessment of angina status and ischemia on stress echo over one year among patients with moderate ischemia on stress imaging and non-obstructive CAD on coronary CT angiography.

Detailed description

Some people with chest pain are found to have open arteries on angiograms instead of blocked arteries and many, but not all, of these people have abnormal stress tests or other tests showing there is not enough blood flow to the heart. Prior research has not made clear whether chest pain in such patients is due to heart disease or something else, in part because no one has found out whether chest pain and stress test results change in the same direction over time. This study will use two measurements of chest pain and two stress tests, one year apart, to find out if chest pain and abnormal stress tests are both caused by the same problem: not enough blood flow to the heart.The association between angina, ischemia and atherosclerosis severity at baseline will be examined, as will medication effects.

Conditions

• Microvascular Angina
• Angina Pectoris

Interventions

Type	Name	Description
OTHER	Quality of Life assessment	Seattle Angina Questionnaire and other questionnaires.
PROCEDURE	Stress imaging	Stress imaging

Timeline

• Start date: 2014-08-01
• Primary completion: 2019-12-01
• Completion: 2019-12-01
• First posted: 2015-01-27
• Last updated: 2020-02-17

Locations

1 site across 1 country: United States