NCT02337465

KV-CBCT and Ultrasound Imaging in Guiding Radiation Therapy in Patients With Prostate, Liver, or Pancreatic Cancer

Integrated 3D X-ray and Ultrasound Guided Radiation Therapy of Soft Tissue Targets

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Case Comprehensive Cancer Center · Academic / Other
• Sex: All
• Age: 19 Years
• Healthy volunteers: Not accepted

Summary

This clinical trial studies if kilo-voltage cone beam computed tomography (KV-CBCT) and ultrasound imaging works in guiding radiation therapy in patients with prostate, liver, or pancreatic cancer. Computer systems, such as KV-CBCT and ultrasound imaging, allow doctors to create a 3-dimensional picture of the tumor may help in planning radiation therapy and may result in more tumor cells being killed.

Detailed description

PRIMARY OBJECTIVES: I. To investigate the feasibility of combining on-board cone beam computed tomography (CBCT) with ultrasound imaging to overcome the shortcomings of CBCT or ultrasound imaging alone for imaging guided radiotherapy delivery. OUTLINE: Patients undergo ultrasound imaging prior to and during radiation therapy. Patients also undergo kilo-voltage cone beam computed tomography prior to radiation therapy. Update (2021/02/04): Removed secondary outcome "Incidence of Adverse Events Related to the Ultrasound Probe". Per PI: Study initially intended to involve a non-FDA approved probe for use with liver patients but removed this section.

Conditions

• Adult Liver Carcinoma
• Malignant Pancreatic Neoplasm
• Prostate Carcinoma

Interventions

Type	Name	Description
DEVICE	Cone-Beam Computed Tomography	Undergo kilo-voltage cone beam computed tomography
RADIATION	3-Dimensional Ultrasound-Guided Radiation Therapy	Undergo ultrasound-guided radiation therapy

Timeline

• Start date: 2015-09-22
• Primary completion: 2019-12-14
• Completion: 2019-12-14
• First posted: 2015-01-13
• Last updated: 2021-02-23
• Results posted: 2021-02-23

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study