NCT02335437

Chronic Fatigue Following Acute Epstein-Barr Virus Infection in Adolescents

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 270 (estimated)
• Sponsor: University Hospital, Akershus · Academic / Other
• Sex: All
• Age: 12 Years – 20 Years
• Healthy volunteers: Accepted

Summary

Chronic fatigue syndrome (CFS) is characterized by unexplained, disabling and long lasting fatigue, as well as pain, impaired memory, sleep difficulties and other symptoms. Epstein-Barr virus (EBV) infection might precipitate CFS. In this study, 200 adolescents undergoing acute EBV infection will be followed prospectively, and also compared with a group of healthy controls. The aim is twofold: * To identify factors that predispose to chronic fatigue among adolescents with acute EBV infection * To compare pathophysiological features of patients with acute EBV infection with a group of healthy controls. Possible risk factors for chronic fatigue 6 months after EBV-infection includes: * Severity of the initial infection * Immune responses characteristics * Characteristics of the neuroendocrine stress response * Cognitive functioning * Emotional disturbances * Genetics/ epigenetics of candidate genes * Certain personality traits * Critical life events

Conditions

• Fatigue Syndrome, Chronic
• Epstein-Barr Virus Infections

Timeline

• Start date: 2015-03-01
• Primary completion: 2016-12-01
• Completion: 2017-06-01
• First posted: 2015-01-09
• Last updated: 2017-06-28

Locations

1 site across 1 country: Norway