NCT02335151

CTC Pancreatic Adenocarcinoma

Resectable Pancreatic Adenocarcinoma - Does the Type of Anesthesia Have an Impact on Circulating Tumor Cells?

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 86 (actual)
• Sponsor: University of Zurich · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

Proportion of circulating tumor cells (CTC) in the postoperative phase after curative tumor removal of pancreatic cancer will be determined and correlated to the accordance of anesthesia (desflurane versus propofol)

Detailed description

This prospective, randomized study will be conducted over a 36-month period to investigate whether commonly used anesthetics (volatile versus intravenous) have an effect on the changes or occurrence of CTC in patients suffering from primary pancreatic cancer undergoing curative surgery. The specific research question is if there are changes of the CTC count in the postoperative phase in the desflurane group (intervention) compared to the propofol one (control). A secondary question is if these changes can be correlated to tumor outcome.

Conditions

• Adenocarcinoma
• Circulating Tumor Cells
• Pancreatic Neoplasms

Interventions

Type	Name	Description
DRUG	Desflurane	Apply desflurane as anesthetic

Timeline

• Start date: 2016-10-01
• Primary completion: 2019-09-01
• Completion: 2019-10-01
• First posted: 2015-01-09
• Last updated: 2019-12-13

Locations

4 sites across 1 country: Switzerland