NCT02334046

Remifentanil for Smooth Emergence in Elderly Patients

Effect-site Concentration of Remifentanil for Preventing Cough During Emergence in Elderly Patients

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 47 (actual)
• Sponsor: Ajou University School of Medicine · Academic / Other
• Sex: All
• Age: 20 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Elderly patients show different pharmacokinetic and pharmacodynamic variables and usually need smaller doses of anaesthetic drugs than younger patients. The purpose of this study was to investigate the optimal effect-site concentration of remifentanil for preventing cough during emergence in elderly patients under sevoflurane and remifentanil anesthesia.

Conditions

• Drug Usage

Interventions

Type	Name	Description
DRUG	Remifentanil	Remifentanil was maintained at predetermined effect-site concentration during the periextubation period (initial concentration: 1.8 ng/ml) in elderly patients (65-80 years) .
DRUG	Remifentanil	Remifentanil was maintained at predetermined effect-site concentration during the periextubation period (initial concentration: 1.8 ng/ml) in adult patients (20-60 years) .
DRUG	Sevoflurane	Anesthesia was maintained with sevoflurane with 1.5-2.0 vol% in air/50%oxygen mixture, and sevoflurane was adjusted to about 1.0 vol% 10 min before end of surgery.

Timeline

• Start date: 2015-02-01
• Primary completion: 2015-11-01
• Completion: 2015-12-01
• First posted: 2015-01-08
• Last updated: 2015-12-18

Locations

1 site across 1 country: South Korea