NCT02333669

Association of SCNN1A Single Nucleotide Polymorphisms With Neonatal Respiratory Distress Syndrome

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 249 (actual)
• Sponsor: Daping Hospital and the Research Institute of Surgery of the Third Military Medical University · Academic / Other
• Sex: All
• Age: 1 Minute – 28 Days
• Healthy volunteers: Accepted

Summary

Lung fluid absorption disorders are largely mediated by transepithelial Na+ reabsorption through alpha epithelial sodium channels (α-ENaCs) in alveolar epithelial cells. Increasing evidence has demonstrated that these lung disorders might be an important cause of neonatal respiratory distress syndrome (NRDS) by influencing gas exchange or surfactant function, particularly in near-term and term infants. The SCNN1A gene, which encodes the α-ENaC, might predispose infants to NRDS. To explore whether the single-nucleotide polymorphisms (SNPs) of SCNN1A are associated with NRDS, we conducted a case-control study to investigate the NRDS-associated loci in Han Chinese infants. Seven target SNPs were selected from the SCNN1A gene and were genotyped using the improved multiplex ligase detection reaction (iMLDR).

Conditions

• Neonatal Respiratory Distress Syndrome

Interventions

Type	Name	Description
OTHER	no intervention	no intervention

Timeline

• Start date: 2012-01-01
• Primary completion: 2014-06-01
• Completion: 2014-12-01
• First posted: 2015-01-07
• Last updated: 2015-01-07

Locations

1 site across 1 country: China